The Voice Sends Two Contestants Home






The Voice










11/13/2012 at 10:20 PM EST







Adam Levine and Christina Aguilera


Christopher Polk/Getty


It was a great night for Teams Cee Lo and Adam on The Voice Tuesday. And though not everyone got good news on elimination night, there were plenty of entertaining performances from the coaches and contestants alike.

To open the night, Christina Aguilera and Green performed the world premiere of "Make the World Move," from her new album Lotus. Guest Jason Aldean also took the stage, and Blake Shelton rocked out with his team to Tom Cochrane's "Life is a Highway."

Green's Trevin Hunte, Nicholas David and Cody Belew came together for a '70s inspired – bell bottoms and all! – performance of the Bee Gee's "Stayin' Alive." But was it a sign of things to come? Keep reading for all the results ...

All of Green's singers as well as Levine's Bryan Keith, Melanie Martinez and Amanda Brown felt the love from viewers at home, and will have another shot at next week's show.

America also saved Aguilera's Sylvia Yacoub and Dez Duron, and Shelton's Cassadee Pope and Terry McDermott.

But without enough votes to keep them in the competition, Team Aguilera's Adriana Louise and Team Blake's Michaela Paige said goodbye.

Aguilera consoled Louise by reminding her that even she didn't win Star Search, but still made it to superstardom. Louise was grateful for all her coach's support. "You believed in me more than I believed in myself," she told Aguilera through tears.

Paige also enjoyed an uplifting experience on The Voice. "If I inspired anyone, that's all I wanted to do," Paige said. "Follow your dreams and believe in your heart." But her coach Shelton isn't too concerned about the aspiring singer's future.

"Her big old mohawk is going to be walking across the stage at the Grammys," he said, "and I can't wait."

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Report: FDA wanted to close Mass pharmacy in 2003

WASHINGTON (AP) — Nearly a decade ago, federal health inspectors wanted to shut down the pharmacy linked to a recent deadly meningitis outbreak until it cleaned up its operations, according to congressional investigators.

About 440 people have been sickened by contaminated steroid shots distributed by New England Compounding Center, and more than 32 deaths have been reported since the outbreak began in September, according to the Centers for Disease Control and Prevention. That has put the Framingham, Mass.-based pharmacy at the center of congressional scrutiny and calls for greater regulation of compounding pharmacies, which make individualized medications for patients and have long operated in a legal gray area between state and federal laws.

The House Energy and Commerce Committee released a detailed history of NECC's regulatory troubles on Monday, ahead of a meeting Wednesday meeting to examine how the outbreak could have been prevented. The 25-page report summarizes and quotes from FDA and state inspection memos, though the committee declined to release the original documents.

The report shows that after several problematic incidents, Food and Drug Administration officials in 2003 suggested that the compounding pharmacy be "prohibited from manufacturing" until it improved its operations. But FDA regulators deferred to their counterparts in Massachusetts, who ultimately reached an agreement with the pharmacy to settle concerns about the quality of its prescription injections.

The congressional report also shows that in 2003 the FDA considered the company a pharmacy. That's significant because in recent weeks public health officials have charged that NECC was operating more as a manufacturer than a pharmacy, shipping thousands of doses of drugs to all 50 states instead of small batches of drugs to individual patients. Manufacturers are regulated by the FDA and are subject to stricter quality standards than pharmacies.

The report offers the most detailed account yet of the numerous regulatory complaints against the pharmacy, which nearly date back to its founding in 1998. Less than a year later, the company was cited by the state pharmacy board for providing doctors with blank prescription pads with NECC's information. Such promotional items are illegal in Massachusetts and the pharmacy's owner and director, Barry Cadden, received an informal reprimand, according to documents summarized by the committee.

Cadden was subject to several other complaints involving unprofessional conduct in coming years, but first came to the FDA's attention in 2002. Here are some key events from the report highlighting the company's early troubles with state and federal authorities:

__ In March of 2002 the FDA began investigating reports that five patients had become dizzy and short of breath after receiving NECC's compounded betamethasone repository injection, a steroid used to treat joint pain and arthritis that's different from the one linked to the current meningitis outbreak.

FDA inspectors visited NECC on April 9 and said Cadden was initially cooperative in turning over records about production of the drug. But during a second day of inspections, Cadden told officials "that he was no longer willing to provide us with any additional records," according to an FDA report cited by congressional investigators. The inspectors ultimately issued a report citing NECC for poor sterility and record-keeping practices but said that "this FDA investigation could not proceed to any definitive resolution," because of "problems/barriers that were encountered throughout the inspection."

__ In October of 2002, the FDA received new reports that two patients at a Rochester, N.Y., hospital came down with symptoms of bacterial meningitis after receiving a different NECC injection. The steroid, methylprednisolone acetate, is the same injectable linked to the current outbreak and is typically is used to treat back pain. Both patients were treated with antibiotics and eventually recovered, according to FDA documents cited by the committee.

When officials from the FDA and Massachusetts Board of Pharmacy visited NECC later in the month, Cadden said vials of the steroid returned by the hospital had tested negative for bacterial contamination. But when FDA scientists tested samples of the drug collected in New York they found bacterial contamination in four out of 14 vials sampled. It is not entirely clear whether FDA tested the same lot shipped to the Rochester hospital.

__ At a February 2003 meeting between state and federal officials, FDA staff emphasized "the potential for serious public consequences if NECC's compounding practices, in particular those relating to sterile products, are not improved." The agency issued a list of problems uncovered in its inspection to NECC, including a failure to verify if sterile drugs met safety standards.

But the agency decided to let Massachusetts officials take the lead in regulating the company, since pharmacies are typically regulated at the state level. It was decided that "the state would be in a better position to gain compliance or take regulatory action against NECC as necessary," according to a summary of the meeting quoted by investigators.

The FDA recommended the state subject NECC to a consent agreement, which would require the company to pass certain quality tests to continue operating. But congressional investigators say Massachusetts Board of Pharmacy did not take any action until "well over a year later."

__ In October 2004, the board sent a proposed consent agreement to Cadden, which would have included a formal reprimand and a three-year probationary period for the company's registration. The case ended without disciplinary action in 2006, when NECC agreed to a less severe consent decree with the state.

Massachusetts officials indicated Tuesday they are still investigating why NECC escaped the more severe penalty.

"I will not be satisfied until we know the full story behind this decision," the state's interim health commissioner Lauren Smith said in a transcript of her prepared testimony released a day ahead of delivery. Smith is one of several witnesses scheduled to testify Wednesday, including FDA Commissioner Margaret Hamburg.

The committee will also hear from the widow of 78-year-old Eddie C. Lovelace, a longtime circuit court judge in southern Kentucky. Autopsy results confirmed Lovelace received fungus-contaminated steroid injections that led to his death Sept. 17.

Joyce Lovelace will urge lawmakers to work together on legislation to stop future outbreaks caused by compounded drugs, according to a draft of her testimony.

"We now know that New England Compounding Pharmacy, Inc. killed Eddie. I have lost my soulmate and life's partner with whom I worked side by side, day after day for more than fifty years," Lovelace states.

Barry Cadden is also scheduled to appear at the hearing, after lawmakers issued a subpoena to compel him to attend.

The NECC has been closed since early last month, and Massachusetts officials have taken steps to permanently revoke its license. The pharmacy has recalled all the products it makes, including 17,700 single-dose vials of a steroid that tested positive for the fungus tied to the outbreak.

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"Fiscal cliff" uncertainty keeps Wall Street subdued

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New Syria opposition seeks recognition; Israel fires from Golan

DOHA/CAIRO (Reuters) - Syria's newly named opposition leader, a soft-spoken cleric backed by Washington and the Gulf Arab states, launched his quest on Monday for international recognition of a government-in-waiting to topple President Bashar al-Assad.


In a sign of the danger that the 20-month civil war could spread across Syria's borders, Israeli forces said they fired "direct hits" on Syrian artillery in response to a mortar strike into the Israeli-occupied Golan Heights.


Western and Arab enemies of Assad hope the creation of a new Syrian National Coalition for Opposition and Revolutionary Forces can finally unify a fractious and ineffective opposition.


Mouaz Alkhatib, a former imam of a Damascus mosque, flew to Cairo to seek the Arab League's blessing for the new assembly, the day after he was unanimously elected to lead it. He made a concerted effort to address the sectarian and ethnic acrimony underlying 20 months of civil war that has killed 38,000 people.


"We demand freedom for every Sunni, Alawi, Ismaili, Christian, Druze, Assyrian ... and rights for all parts of the harmonious Syrian people," he said, calling on Syrian soldiers to desert and all sects to unite.


His assembly was recognised by the six Sunni Muslim-ruled kingdoms of the Gulf Cooperation Council as the "legitimate representative of the Syrian people". Washington said it would back it "as it charts a course toward the end of Assad's bloody rule and the start of the peaceful, just, democratic future".


Shooting across the line that divides Syria from the Israeli-occupied Golan was just the latest spillover of violence that has alarmed neighbors including Turkey and Lebanon.


Israeli military sources said Israel hit Syrian army mobile artillery on Monday, the second straight day it fired back in retaliation for what it said were stray mortars hitting Golan.


"We will not allow our borders to be breached or our citizens to be fired at," Prime Minister Benjamin Netanyahu said. Israel seized the Golan Heights from Syria in 1967. Although the two countries have not fought over the territory since 1973, they are still officially at war.


U.N. Secretary-General Ban Ki-Moon called on Israel and Syria to halt firing.


In the north, where fighting has sent thousands of Syrian refugees fleeing into Turkey, a Reuters correspondent saw Syrian jets and helicopters bomb Ras al-Ain, a border town taken by rebels last week. Bombs landed just meters from the frontier, sending up plumes of black smoke.


Opposition groups said 12-16 people died in the air strikes. Turkey said it did not appear that the planes had entered its air space. It is discussing with NATO allies deploying Patriot air defense missiles on the border.


WRANGLING


Rebels and opposition politicians formed Alkhatib's new opposition coalition after days of wrangling in Qatar under intense U.S. and Qatari pressure.


Backers hope the new body will give rebels inside Syria more clout and reassure religious and ethnic minorities, after a Syrian National Council (SNC) made up mainly of exiled Islamists proved ineffective as the main opposition voice.


Western and Arab opponents of Assad want the coalition to attract support from minority sects who had been alienated from the opposition by the prominence of well-organized Sunnis from the Muslim Brotherhood. They also hope to rein in Islamist fighters, some of whom they believe are linked to al Qaeda.


"Alkhatib is a dynamic, progressive Islamist, popular in Damascus and the rest of Syria," said Mazen Adi, a prominent Syrian human rights defender who worked with Alkhatib before the revolt. "He is not a trigger-happy Jihadist, and he can play a role in containing the extremist groups."


Alkhatib met Arab League chief Nabil Elaraby before the gathering of Arab foreign ministers in Cairo. European foreign ministers are due to join them on Tuesday.


"The most important thing that could come out from (Monday's) meeting is a form of recognition for the new Syrian council alliance that was established in Doha," said one Arab diplomat, speaking before the talks on condition of anonymity.


A League official said any recognition of the opposition would probably avoid describing it as the sole legitimate representative of the Syrian people, because some Arab states were still reluctant to jettison Assad.


"There are still Arab states like Iraq and Lebanon that are not fully supportive of the Syrian revolt," the official said, also on condition he not be identified.


Alkhatib, in his early 50s, was jailed several times for criticizing Assad before fleeing into exile this year. He has long promoted a liberal Islam tolerant of Syria's Christian, Alawite and other minorities, activists say.


Hassan Hassan, a Syrian commentator based in the United Arab Emirates, said Alkhatib, as an independent cleric, would be a counterweight to growing influence of the Muslim Brotherhood.


"He's been active for a long time, campaigning against the idea of retribution and extremism. He talks about liberty and freedom for the masses. So he is perceived as a credible figure," Hassan said.


Russia, which with China has foiled U.N. action on Syria and views Assad's opponents as pawns of the West, urged the new body to negotiate and to reject outside meddling.


Asked if China recognised the new coalition, Foreign Ministry spokesman Hong Lei called on all parties to initiate "a political transition process guided by the Syrian people".


It remains to be seen whether the Coalition can succeed where the exiled SNC failed in overcoming mutual suspicion and in-fighting that weakened the opposition.


"This is a significant step forward, because they finally seem to be forging a more broadly-based platform that includes the SNC but without the SNC taking the lion's share," said Salman Shaikh, director of the Doha Brookings Center think tank.


(Additional reporting by Andrew Hammond in Doha, Khaled Yacoub Oweis in Amman, Jonathon Burch in Ceylanpinar, Crispian Balmer in Jerusalem, Arshad Mohammed in Washington, Michael Martina in Beijing, Steve Gutterman in Moscow, Regan Doherty in Doha and Ayman Samir in Cairo; Writing by Peter Graff; Editing by Giles Elgood and Philippa Fletcher)


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Ads are Invading Gadgets and Apps that You Already Paid For
















Most of us are used to seeing ads on stuff that we get for free, like smartphone and tablet apps or online news websites. But you’re probably also used to being able to pay to remove ads, whether by getting the premium version of an app or even upgrading to a new computer that doesn’t have so much garbage on it.


As it turns out, this strategy doesn’t work so well anymore. That’s because companies are starting to put “special offers” all over things that you buy … and this time, it’s not just the usual preinstalled trashware. Here’s a look at some of the latest strikes in the war for your attention.













Microsoft: Xbox Music and Xbox Live


Last year’s redesign of the Xbox 360 dashboard featured prominent ads, including videos that played automatically, even if you were paying for a $ 60/year Xbox Live Gold membership. This year, Microsoft introduced its new Xbox Music Pass, which allows you to stream millions of songs to your Xbox 360 or Windows 8 PC. It has an ad-supported free trial mode, which lets you listen to songs (and ads) for free for the first six months before imposing a monthly listening limit.


But according to Neowin.net editor Owen Williams, the ads stay even if you pay $ 99 per year for the subscription service. On top of that, you can’t use Xbox Music on the actual Xbox at all (beyond a 30-day trial) unless you also​ pay for an Xbox Live Gold Subscription. That’s almost $ 160 per year for two separate subscriptions, and in return you apparently get twice the ads.


​Microsoft: Windows 8


If the ads in the Xbox Music service aren’t enough, Microsoft has also put ads all over its Windows 8 operating system. Whether you buy a new Surface tablet or you pay for the upgrade from Windows 7 such as through buying a separate boxed copy, you still have to contend with ads in “many of the bundled [Modern] UI applications,” according to Williams.


Amazon: The entire Kindle lineup


Amazon began selling Kindle e-readers with “special offers” a while back. These appeared on the lock screen, and replaced the normal screen saver, which was more literary.


When Amazon announced its new lineup of Kindle Fire HD tablets not too long ago, it turned out that every single one of them had advertisements. Not just on the lock screen, but now even in a corner on the home screen while you’re browsing through your books and apps.


At the time, Amazon wasn’t offering any way to get rid of these ads on the new Kindle Fire HD, but the company now gives people the option to buy Kindles sans ads for an extra $ 15. That won’t help you with in-app ads, though, if you use free apps.


Jared Spurbeck is an open-source software enthusiast, who uses an Android phone and an Ubuntu laptop PC. He has been writing about technology and electronics since 2008.


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Robert Pattinson & Kristen Stewart Attend Breaking Dawn - Part 2 Premiere Together















11/12/2012 at 10:45 PM EST







Kristen Stewart and Robert Pattinson


Matt Sayles/Invision/AP


Robert Pattinson and Kristen Stewart are back together – as a couple and now on the red carpet.

On Monday night, they attended their first public Hollywood event together since the cheating scandal that rocked their relationship in July.

The occasion, of course, was the Los Angeles premiere of The Twilight Saga: Breaking Dawn – Part 2.

Stewart, 22, and Pattinson, 26 – who split after she had a tryst with her Snow White and the Huntsman director Rupert Sanders, but later reconciled – walked the carpet amid cheers from throngs of fans at the Nokia Theater L.A. LIVE.

The couple, who posed side-by-side, even complimented each other in their glamorous duds: She wore a light brown gown and he donned a slim-fitting forest green suit.

Twihards have been anxiously awaiting the couple's public debut – and of course, the final installment of the Twilight series, which opens Friday.

Until the film's premiere, the couple had only united away from the fans for media interviews or to quietly duck into parties.

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British medical journal slams Roche on Tamiflu

LONDON (AP) — A leading British medical journal is asking the drug maker Roche to release all its data on Tamiflu, claiming there is no evidence the drug can actually stop the flu.

The drug has been stockpiled by dozens of governments worldwide in case of a global flu outbreak and was widely used during the 2009 swine flu pandemic.

On Monday, one of the researchers linked to the BMJ journal called for European governments to sue Roche.

"I suggest we boycott Roche's products until they publish missing Tamiflu data," wrote Peter Gotzsche, leader of the Nordic Cochrane Centre in Copenhagen. He said governments should take legal action against Roche to get the money back that was "needlessly" spent on stockpiling Tamiflu.

Last year, Tamiflu was included in a list of "essential medicines" by the World Health Organization, a list that often prompts governments or donor agencies to buy the drug.

Tamiflu is used to treat both seasonal flu and new flu viruses like bird flu or swine flu. WHO spokesman Gregory Hartl said the agency had enough proof to warrant its use for unusual influenza viruses, like bird flu.

"We do have substantive evidence it can stop or hinder progression to severe disease like pneumonia," he said.

In the U.S., the Centers for Disease Control and Prevention recommends Tamiflu as one of two medications for treating regular flu. The other is GlaxoSmithKline's Relenza. The CDC says such antivirals can shorten the duration of symptoms and reduce the risk of complications and hospitalization.

In 2009, the BMJ and researchers at the Nordic Cochrane Centre asked Roche to make all its Tamiflu data available. At the time, Cochrane Centre scientists were commissioned by Britain to evaluate flu drugs. They found no proof that Tamiflu reduced the number of complications in people with influenza.

"Despite a public promise to release (internal company reports) for each (Tamiflu) trial...Roche has stonewalled," BMJ editor Fiona Godlee wrote in an editorial last month.

In a statement, Roche said it had complied with all legal requirements on publishing data and provided Gotzsche and his colleagues with 3,200 pages of information to answer their questions.

"Roche has made full clinical study data ... available to national health authorities according to their various requirements, so they can conduct their own analyses," the company said.

Roche says it doesn't usually release patient-level data available due to legal or confidentiality constraints. It said it did not provide the requested data to the scientists because they refused to sign a confidentiality agreement.

Roche is also being investigated by the European Medicines Agency for not properly reporting side effects, including possible deaths, for 19 drugs including Tamiflu that were used in about 80,000 patients in the U.S.

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Online:

www.bmj.com.tamiflu/

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